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Author

Ralph A. DeFronzo

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2 papers indexed here

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Open access Oct 2026

Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation.

Skeletal muscle tissue underlies several polygenic metabolic traits and diseases. Identifying their genetic mechanisms requires pinpointing cell types, regulatory elements, target genes and causal variants. Here we use genetic multiplexing to generate population-scale single-nucleus chromatin accessibility (single-nucl...

Arushi Varshney, Nandini Manickam, Peter Orchard et al. · 0 citations
Review Oct 2026

Cortisol in cardio-kidney-metabolic disease.

Despite guideline-directed therapy, many patients with cardio-kidney-metabolic (CKM) disease remain uncontrolled due to therapeutic inertia, adherence barriers, and underrecognized secondary causes. Hypercortisolism, ranging from mild autonomous cortisol secretion (MACS) to overt Cushing syndrome, is an increasingly re...

Muhammad Shahzeb Khan, Muhammad Sameer Arshad, Deepak L. Bhatt et al. · 0 citations

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