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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ralph Röth

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Open access Oct 2026

KCNQ1 disruption alters human neuronal development through mitochondrial and insulin signalling pathways

KCNQ1 encodes a voltage-gated potassium channel implicated in peripheral and neurological disorders, but its role in human neurodevelopment remains unclear. We generated KCNQ1 knockout (KO) human induced pluripotent stem cells and differentiated them into neural stem cells (NSCs) and cortical neurons. KCNQ1-deficient N...

Dorothea Schall, B. Guler, Siamand Alibrahim et al. · 0 citations
Open access Sep 2026

Small extracellular vesicles from the plasma of head and neck cancer patients induce dysfunctional T cell phenotypes.

BACKGROUND Head and neck cancer (HNC) is highly immunosuppressive. Despite advances with immune checkpoint (IC) inhibitors, many HNC patients fail to respond. Tumour-derived small extracellular vesicles (sEVs) may contribute to immune evasion and therapy resistance, possibly by altering T-cell phenotypes. METHOD Plas...

Luisa Tengler, Edwin K. Jackson, K. Bieback et al. · 0 citations

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