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Ramadevi Chilamkurthy

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Open access Aug 2026

CRISPR RNA architecture steers Cas9 catalysis and fidelity via a guide repeat clasp motif

A previously unknown mechanism that steers Cas9 catalysis is uncovered and the potential to improve Cas9 fidelity by modulating guide repeat interactions is demonstrated.

Ramadevi Chilamkurthy, Sruthi Sudhakar, Adrian A. Pater et al. · 0 citations