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Ramhari Kumbhar

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Open access Jul 2026

Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras.

Findings indicate that PMO-based RNA-degrading chimeras (RDCs) that selectively bind the 5' untranslated region of SNCA messenger RNA (mRNA) and recruit RNase L for targeted RNA degradation may represent a promising therapeutic modality for α-synucleinopathies.

Ning Wang, Shalakha Hegde, Zhichao Tang et al. · 0 citations

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