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Author

Ran Gao

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Open access Aug 2026

PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin‐proteasome system

Abstract Background All‐trans retinoic acid (ATRA) exerts its biological functions primarily through nuclear receptors, but its therapeutic efficacy in solid tumours remains limited. This study aimed to elucidate the regulatory role of the cancer‐testis antigen PRAME in posttranslational modifications (PTMs) of the ATR...

Xu-Dong Wang, Ting-Yao Ma, Yi-Xin Jing et al. · 0 citations
Open access Jul 2026

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

An NSD2‐H3K36me2‐EGFR‐EGFR‐ERK axis that drives cortical gliogenesis is defined and mechanistic insights into the potential contribution of NSD2 deficiency to neurodevelopmental abnormalities are provided.

Hanxue Chen, Mengyuan Li, Lin Hou et al. · 0 citations

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