Potential Contribution of the Microbiota-Gut-Brain Axis to Doxorubicin-Associated Cognitive Impairment: Mechanisms, Evidence, and Therapeutic Opportunities.
Chemotherapy-induced cognitive impairment (CICI), often termed chemobrain, is a clinically important complication of cancer treatment that can affect memory, attention, executive function, and processing speed during and after therapy. Doxorubicin is of particular mechanistic interest because brain parenchymal exposure...