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Author

Rand O. Shahin

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Open access Sep 2026

Discovery of novel acridine based inhibitors of Bruton’s tyrosine kinase (BTK) via pharmacophore modeling and machine learning-driven virtual screening followed by molecular dynamic studies

A key outcome of this study is the identification of a chemically distinct and novel, acridine-based antiproliferative hit candidates with measurable BTK inhibitory activity.

Rand O. Shahin, Sawsan Jaafreh, Iman A. Mansi et al. · 0 citations
#graph neural networks Review Open access Aug 2026

Bridging the antiviral drug design gap: a combined machine learning and QSAR approach for drug repurposing of host kinase inhibitors

Viral outbreaks combined with rapid emergence of mutated viruses have highlighted an urging need for accelerating antiviral drug discovery pipelines. Unfortunately, current drug discovery remains stuck to conventional methods which are slow especially during pandemics. In this article, we present a literature-based syn...

Rand O. Shahin, Yusra Azzam, Salma Azzam · 0 citations

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