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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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RanJu Woo

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Open access Aug 2026

Stage-dependent doxorubicin toxicity impairs C2C12 myogenesis via AMPK/AKT-FOXO signaling and is attenuated by metformin.

Doxorubicin (DOX) can compromise skeletal muscle, but whether toxicity depends on myogenic stage is unclear. C2C12 myoblasts were exposed to non‑cytotoxic DOX (0.025-0.1μg/mL) before differentiation (24h) or after 3 days of differentiation (48h), with or without metformin (Met; 0.1-2mM). Pre‑differentiation DOX markedl...

S. Kim, C. Ryu, Chawon Yun et al. · 0 citations

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