Author

Raphaël Guérois

2 papers indexed here

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Open access Jul 2026

Machine Learning-Guided Engineering of High-Affinity Cross-Reactive Antibodies with Minimal Mutations

A Deep Mutational Scanning-coupled deep learning strategy to engineer potent cross-reactive antibodies with minimal sequence divergence that retained PD-1/PD-L1 blockade and demonstrated therapeutic activity in a mouse tumor model is developed.

H. Dorison, Anne-Laure Grindel, François Thenier et al. · bioRxiv · 0 citations

Open access Aug 2026

Downsizing the Histone H3-H4 Quaternary Structure Into Foldamer Mimetics Yields High-Affinity and Cell-Permeable Ligands of ASF1.

Mimicking complex protein-protein interfaces with small, well-defined molecular scaffolds remains a major challenge in chemical biology. Here, we report a foldamer-based downsizing strategy that compresses the quaternary architecture of the histone H3-H4 dimer into compact peptide-oligourea hybrids acting as high-affin...

Bo Li, Marie E. Perrin, Emma Maillard et al. · Angewandte Chemie · 0 citations