Raphael Luiz Lobo da Silva Souza

From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits

Abstract Purinergic signaling represents an ancient intercellular communication system. Operating at the interface between bioenergetic metabolism and damage detection, extracellular purines such as adenosine 5′-triphosphate (ATP) and adenosine (ADO) are recruited into the nervous system for neurotransmission and homeo...