Ratnesh Jain

Mechanistic evaluation of sulfobutylether-β-cyclodextrin complexation as a formulation strategy to enhance solubility and oral exposure of BCS Class II compounds.

Poor aqueous solubility is a major cause of solubility-limited absorption and misleading pharmacokinetic outcomes during early oral drug discovery. In this study, a mechanistically guided workflow was applied in which physiologically based absorption modeling using GastroPlus®, followed by refined development classific...