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OpenKinetics Predictor (predictor.openkinetics.org), an open-source platform integrating thirteen kinetic parameter prediction methods accessible via one interface, is presented, finding inter-predictor agreement varies with metabolic context and data availability.
Abstract Predicting enzyme kinetics directly from sequence remains a central challenge in computational biology, particularly for mutations at catalytically essential residues. Existing models often default to wild-type predictions even when mutations cause substantial activity loss. This limits their utility for enzym...
Esca is introduced, a sequence-only toolchain framework that identifies immune escape-prone residues by exhaustively scanning each residue position for all amino acid substitutions using a Bayesian Variational Autoencoder trained on protein language model embeddings, supporting surveillance of emerging PRRSV variants.
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