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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Raul Urrutia

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Open access Aug 2026

Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis.

Pancreatic ductal adenocarcinoma (PDAC) is initiated by activating KRAS mutations, yet most pancreatic cells fail to survive the induced oncogenic stress. How a subset adapts to and initiates malignant transformation remains unclear. Here, we show that stress granules (SGs) formation is a key adaptive mechanism enablin...

Matías Estarás, Emma Cosialls, Gareth Pollin et al. · 0 citations

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