Open access
Aug 2026
Loss of the high-affinity vacuolar Ca2+ pump Pmc1p confers echinocandin tolerance in Candida albicans through enhancing calcineurin-based responses
Signaling through the calcium-activated calcineurin phosphatase promotes fungal survival of stressful conditions including those imposed by antifungal medications. Calcium is an essential secondary messenger that regulates diverse cellular processes in eukaryotes; however, it is also profoundly toxic and cytoplasmic co...
J. Gregor, Ravinder Kumar, C. DeJarnette et al.
· bioRxiv · 0 citations