Ravinder Reddy Patlolla

Development of an efficient chemo-enzymatic process for the synthesis of Nilotinib

Nilotinib is one of the important second-generation tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia. The synthesis of Nilotinib involves expensive intermediates like carboxylic acids. Traditional methods of such intermediates involve chemical hydrolysis using acids or bases, leading to the...