Ravindra K. Gupta

Coevolving Mutations in Chronic SARS-CoV-2 Infections

A collection of over 3000 independent, full-length SARS-CoV-2 sequences deriving from posited or confirmed chronic infections is assembled and 14 distinct mutation patterns (MPs) that repeatedly appear in these sequences are described, including four CD8 T cell-escape MPs and two MPs that represent adaptation to tissue compartments outside the upper-respiratory tract.