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Rayssa de Mello Lopes

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Open access Aug 2026

Natural Metabolites from Tabebuia aurea Reveal Isoform-Specific and Cooperative Modulation of Cathepsins B and L.

The development of isoform-selective inhibitors for homologous cysteine proteases remains challenging due to structural similarity and overlapping specificities. Metabolites isolated from Tabebuia aurea were investigated as modulators of Cathepsins B and L. Bioassay-guided fractionation yielded three compounds: 2,3-DH-...

Marli de Fátima Corrêa Emiliano, Mariele R. S. Gonçalves, L. M. R. de Novais et al. · 0 citations

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