Open access
Sep 2026
Development and Characterization of a Hydrogel Incorporating Protamine–Hyaluronic Acid Nanoparticles Co-Loaded with Disulfiram and Coumarin for Diabetic Wound Healing
Background: Diabetes-associated wound healing is frequently impaired due to persistent hyperglycemia, which causes vascular dysfunction and neuropathy, thereby delaying tissue repair. Objectives: In this study, hyaluronic acid and protamine nanoparticles (HA-PRO-NPs) were developed and optimized to encapsulate disulfir...
Zainab Lafi, Mohammad I. A. Ahmad, S. Nusair et al.
· Pharmaceutics · 0 citations