Rebecca A. Segal

Intestinal Alkaline Phosphatase Interaction Gut Model

High fat Western diet (WD) is known to alter the composition of gut microbiota causing the release of lipopolysaccharide (LPS) (Cani et al. 2007). LPS is a TLR4 ligand, produced by Gram-negative bacteria, and is a potent inducer of various inflammatory cytokines. Inflammation in the gut can promote leaky gut syndrome w...