Rebecca Croasdale-Wood

Generative Language Modeling for Antibody CDR Grafting and Alignment-driven De Novo Design

Antibodies recognise their targets through hypervariable complementarity-determining regions (CDRs), which are interleaved with conserved frameworks in sequence space, making de novo CDR design an infilling problem. Autoregressive models generate residues left-to-right, which precludes full framework context during CDR...