Author

Rebecca L. Harper

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Open access Aug 2026

Establishment of human induced pluripotent stem cell lines and isogenic gene-corrected controls from three patients with prolidase deficiency.

Prolidase deficiency is an autosomal recessive inborn error of metabolism caused by pathogenic variants in the PEPD gene. To date, close to 200 patients have been reported worldwide with a poorly understood pathomechanism. The PEPD gene encodes an enzyme that is involved in the final steps of collagen degradation. Urin...

R. Suri, Kevin Emmerich, Sahana Manohar-Sindhu et al. · Stem Cell Research · 0 citations

Open access Aug 2026

Tissue-specific metabolomics in experimental HFpEF reveals hepatic remodelling modulated by SGLT2 inhibition

It is suggested that extra-cardiac metabolic pathways, particularly liver-centered mechanisms, may contribute to the therapeutic benefits of SGLT2 inhibitors in HFpEF and provide new insights into inter-organ metabolic regulation.

M. Kiyar, Ruth R Magaye, Shanae Bailey et al. · Cellular and Molecular Life... · 0 citations