Open access
Aug 2026
Shared and distinct gain-of-function consequences from pathologic cytoplasmic versus nuclear TDP-43
New models with inactivating mutations in the nuclear localization sequence of TDP-43 are generated and phosphorylation-mediated neurotoxicity of both cytoplasmic and nuclear localized TDP-43 is controlled by the phosphatase calcineurin.
Aaron Long, Heather N Currey, Matvey Goldberg et al.
· Cell Death & Disease · 0 citations