Author

Rebecca S. Shapiro

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Open access Sep 2026

Differential requirement for the Ire1 luminal domain in Candida albicans drug susceptibility and pathogenicity

The opportunistic human pathogen Candida albicans depends on the unfolded protein response (UPR) for cell wall integrity, antifungal tolerance, filamentous growth, and virulence. The UPR is driven by the conserved transmembrane sensor Ire1, which is activated either by misfolded proteins through its luminal domain or b...

Samuel Stack-Couture, Nathan Towriss, I. Skulska et al. · bioRxiv · 0 citations

Open access Aug 2026

CRISPR-activation reveals key resistance genes and vulnerabilities of copy number variants in Candida albicans

Additive fitness effects of individual gene overexpression are a significant predictor of the fitness of multiple isolates with CNVs and can explain fitness trade-offs observed between classes of antifungal drug for the CNV isolates.

Pétra L. Vande Zande, Nicholas C. Gervais, Erika Schell et al. · bioRxiv · 0 citations

Open access Jul 2026

Chromosome-scale CRISPR screening reveals secretory pathway genes as drivers of aneuploidy-mediated antifungal tolerance

This work functionally dissects one of the most common aneuploidies observed in C. albicans, provides mechanistic insight into the molecular basis of antifungal tolerance, and establishes a generalizable framework for studying aneuploidy-mediated phenotypes across eukaryotic organisms.

Nicholas C. Gervais, Lauren F. Wensing, Manini Chhina et al. · bioRxiv · 0 citations