Open access
Jul 2026
Pharmacologically regulated bioorthogonal stabilization domain for regulation of CAR T cells
This work fuses tamoxifen-responsive ER ligand-binding domains to CARs to generate ligand-inducible ON-switch CARs whose stability, signaling, and effector functions are precisely controlled by 4-hydroxytamoxifen.
Erik Rihtar, Tina Fink, Monika Belak et al.
· bioRxiv · 0 citations