Open access
Oct 2026
Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology.
OBJECTIVE Early phenotypic presentation of central afferent synapse dysfunction within patients with spinal muscular atrophy (SMA) represents a key target for therapeutic development; however, the underlying disease mechanisms remain unresolved. By further investigating motor neuron synapse and peri-synaptic astrocyte...
Emily Welby, Xiao-Jie Liu, Melinda Wojtkiewicz et al.
· Annals of Neurology · 0 citations