Open access
Jul 2026
Affinity-enhanced peptides delivered by mRNA–LNPs inhibit influenza A virus replication by disrupting the PA-PB1 interaction
This work establishes intracellularly expressed peptide inhibitors as a viable antiviral strategy and provides a generalizable framework for targeting essential protein-protein interactions of influenza and other RNA viruses.
Alberto Florez Prada, Chloé Sturmach, Nabila Laroui et al.
· bioRxiv · 0 citations