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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ren-Jie Li

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Open access Sep 2026

Structural basis of the transport mechanism of hBGT1

In the kidney and liver, the betaine/γ-aminobutyric acid (GABA) transporter 1 (BGT1) transports betaine to maintain the osmotic balance of renal medullary cells and reduce the toxicity of homocysteine accumulation. In the brain, BGT1 reuptakes GABA from the synaptic cleft into glial cells to terminate GABAergic signali...

Kun Hao, Jia-Hui Chen, Jun Zhao et al. · 0 citations
Open access Sep 2026

Substrate recognition and ion coupling mechanism of the human VIAAT

Inhibitory neurotransmission, essential for neural circuit homeostasis and proper neurological function, depends on the efficient sequestration of γ aminobutyric acid (GABA) and glycine into synaptic vesicles. This critical process is mediated exclusively by the vesicular inhibitory amino acid transporter (VIAAT). Desp...

Yi-Qing Wei, Kun-Peng Ma, Kun Hao et al. · 0 citations

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