In locally advanced gastric cancer, a substantial number of patients relapse with liver metastasis months after an apparently curative operation, and standard tumor staging offers little warning of who is at risk. Here, we develop the Radiopathomics-Clinical Stratification Assessment (RCSA), an interpretable model that...
ABSTRACT Inducing pyroptosis in tumor cells has emerged as a promising anticancer strategy. However, under sublethal oxidative stress, a considerable fraction of cancer cells evades pyroptosis and undergoes therapy‐induced senescence, which ultimately drives chronic inflammation and facilitates tumor relapse. Here, we...
Zi-Lu Chen, Kun Mei, Yan Yang et al.· Advancement of science· 0 citations
Three-dimensional (3D) bioprinting is increasingly used to construct patient-relevant tumor models, but its value for precision oncology depends on how functional biomaterials connect tissue reconstruction with therapeutic exposure and response measurement. This review presents a function-oriented framework for advance...
Si-Qi Li, Ren-Jun Gu, Xi-Yi Feng et al.· International Journal of Bio...· 0 citations
: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death worldwide, posing a significant global health burden. Multikinase inhibitors (MKIs) such as sorafenib and lenvatinib are standard therapies for advanced HCC, yet most patients eventually develop drug resistance and tumor relapse, largely a...
