Tebuconazole (TEB) is a widely used triazole fungicide with suspected endocrine-disrupting and reproductive toxicity. However, its effects on human placental trophoblasts and its association with unexplained recurrent pregnancy loss (RPL) remain poorly defined. Chorionic villi from 27 women with unexplained RPL and 25...
Shao-Wei Wang, Hui-Yi Che, Xi-Ya Ren et al.· Ecotoxicology and Environmen...· 0 citations
Steroid 5α-reductase type 1 (SRD5A1) catalyzes the rate-limiting reduction of progesterone to 5α-dihydroprogesterone, the committed step toward allopregnanolone, a positive allosteric modulator of γ-aminobutyric acid type A (GABAA) receptors. Its clinical relevance is shown by allopregnanolone therapeutics for postpart...
Xin-Miao Lu, Jia-Qi Chen, Hao-Nan Fang et al.· Ecotoxicology and Environmen...· 0 citations
Tetrachlorobisphenol A (TCBPA) is a widely used flame retardant with potential endocrine-disrupting properties. This study investigated the effects of TCBPA on steroidogenesis in pubertal rat Leydig cells, focusing on copper homeostasis and on whether the cuproptosis pathway is engaged. Male Sprague-Dawley rats (35 day...
Pu-Tian Zhang, Hao-Nan Fang, Zi-Jian Lin et al.· Ecotoxicology and Environmen...· 0 citations
Industrial phenolic compounds (IPCs) are widespread environmental contaminants with known endocrine-disrupting potential. This study aimed to investigate the inhibition of 13 IPCs on human and rat 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), a crucial enzyme responsible for cortisol inactivation. The inhibitory poten...
Lu-Bin Xie, Lei Shi, Yun-Bing Tang et al.· Ecotoxicology and Environmen...· 0 citations
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