Oct 2026
Enantioselective Synthesis of Chiral 3-Substituted Tetrahydroquinolines via a Pd-Catalyzed C–C Cleavage/C–C Coupling Sequence
A palladium-catalyzed asymmetric synthesis of 3-substituted tetrahydroquinolines (THQs) through a C–C cleavage/C–C coupling sequence has been developed. By employing Pd(OAc)2/Josiphos L7 as the catalyst, an array of chiral tetrahydroquinolines bearing a C3-ketone pendant was afforded in good to excellent yields and e...
Cheng-Yu Li, Xiao-Jing Liu, Zhen-Ting Mao et al.
· Organic Letters · 0 citations