Ren-Ying Wang

Design, synthesis and anti-inflammatory evaluation of arylamide-modified pyrrolo[2,3-d]pyrimidine derivatives against acute lung injury.

Acute lung injury (ALI) is a severe inflammatory disorder for which effective therapeutic options remain limited. In this study, a series of novel pyrrolo[2,3-d]pyrimidine derivatives bearing amide or sulfonamide moieties were synthesized and evaluated for their anti-inflammatory activities. Structure-activity relation...