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Renata G. Almeida

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Open access Aug 2026

Prodrug-like Quinone Containing Two Redox-Active Centers Induces Ferroptosis in Prostate Cancer Cells with Cytotoxic Action Partially Depending on NAD(P)H Quinone Dehydrogenase 1 (NQO1)

Naphthoquinones are redox-active compounds with antitumor potential, often linked to NQO1 overexpression in cancer cells. This study evaluated the cytotoxic activity of two synthetic 1,4-naphthoquinones, compound 1 and its dual redox analog, compound 4, against NQO1-overexpressing DU-145 prostate cancer cells through i...

E. N. Mendoza, Maria Fernanda Madrid, P. M. D. da Costa et al. · 0 citations

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