Open access
Aug 2026
Dysregulated adult hippocampal neurogenesis in major depressive disorders.
A neurogenic lineage in the adult human hippocampal subgranular zone is identified and evidence for a stalled neurogenic process in MDD is provided, associated with transcriptional regulation, stress-related reprogramming and interferon signaling across developmental stages.
Madeleine S Peng, Jia-Jia Jiang, Luciana Polizzi et al.
· Nature Medicine · 2 citations