Open access
Aug 2026
B-cell depletion improves therapeutic index of combination checkpoint blockade in patients with advanced melanoma.
BACKGROUND Combined checkpoint blockade (CCB) of programmed-death-1 (PD-1) and cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4) is highly active in melanoma but limited by significant morbidity from immune-related adverse events (irAEs). Effective strategies to prevent CCB-mediated irAEs are lacking. METHODS Pati...
Kavita M. Dhodapkar, Antonio Matera, Alyssa M. Duffy et al.
· Journal of Clinical Investig... · 0 citations