Author

Rhiju Das

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Open access Sep 2026

FAST-MaP: Chemical Mapping of RNA Structures Using Primer-less Sequencing

RNA structure governs the function of non-coding RNAs and influences mRNA stability and translation, making testing of models of experimental RNA structure relevant to fields spanning structural biology, virology, and molecular therapeutics. Here we present FAST-MaP (Fast and Accessible Sequencing Technology for Mutati...

Jigyasa Verma, Hamish M. Blair, W. Kladwang et al. · bioRxiv · 0 citations

Open access Aug 2026

De novo design of RNA pseudoknots with deep learning.

It is shown that intricate RNA structures can be generated with current deep learning tools through accurate de novo design of pseudoknot secondary structures, suggesting that some difficult RNA design tasks may be tractable without first solving RNA 3D structure prediction.

J. Townley, W. Kladwang, David Baker et al. · Science · 1 citation

Open access Aug 2026

Cryo-EM of a nucleotide-polymerizing ribozyme enables its predictive improvement

Results suggest that accelerating RNA structure determination may speed progress toward nucleotide-based self-replication and suggest that accelerating RNA structure determination may speed progress toward nucleotide-based self-replication.

Deni Szokoli, J. Hingey, V. Wu et al. · bioRxiv · 1 citation