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Author

Rhyston Broadhurst

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2 papers indexed here

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Open access Oct 2026

Targeting SERPINB5 and MSLN for Pancreatic Cancer Therapy

Background/Objectives: Pancreatic cancer (PC) is a leading cause of cancer-related death in the United States and lacks efficient therapeutic options. Serine peptidase inhibitor, clade B, member 5 (SERPINB5) is non-inhibitory toward serine proteases, yet it has diverse biological functions, including regulating cell mi...

Jing-Hui Sun, Ling-Ling Liu, Rhyston Broadhurst et al. · 0 citations
Open access Jul 2026

The Missense Mutant ClC-5 (E211A), associated with Proton/Chloride Uncoupling Exacerbates Renal Pathology Compared to the ClC-5 null Mutant.

The results reveal that uncoupling mutations can drive progressive kidney damage through mechanisms distinct from gene knockout and highlight the need for mutation-specific therapeutic strategies for Dent disease type 1.

Aykut Bostancı, Pin Lyu, Cuili Jiang et al. · 0 citations

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