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Richard G. Held

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Open access Aug 2026

Cryo-Electron Tomography Reveals Nanoscale Thick Filament Disorganization in MYH7 P710R Hypertrophic Cardiomyopathy Cardiomyocytes

Hypertrophic cardiomyopathy (HCM) is the most common monogenic inherited heart disease and is a major cause of sudden death in individuals under 35 years of age. HCM is associated with progressive tissue-level disarray and subcellular disorganization in individual cardiomyocytes. Mutations in β-cardiac myosin (MYH7),...

Magda Zaoralová, Joseph Yoniles, Prerna Giri et al. · 0 citations

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