Open access
Sep 2026
Intratumor delivery of a novel plasmid combination induces high levels of metastatic melanoma regression.
Direct intratumoral administration of immune-stimulating agents can generate systemic immunity following a tumor-localized immune response. Interleukin 12 (IL-12) activates T cells and reverses immunosuppression, generating a localized patient-antigen-specific immune response. Changes in the tumor microenvironment in r...
L. Heller, Julie Singh, Jody C. Synowiec et al.
· Gene Therapy · 0 citations