Open access
Aug 2026
A pathological phosphorylation pattern enhances tau cooperativity on microtubules and facilitates tau filament assembly
Investigating how differential phosphorylation affects microtubule binding, cooperative tau envelope formation, and NFT-relevant filament assembly finds that phosphorylation more dramatically impacts cooperativity between tau molecules during envelope formation.
Xiangyu Fan, Joey B. Truong, Kyoko Okada et al.
· Communications Biology · 0 citations