Author

Richard K. Lacher

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Open access Sep 2026

Atlas-Based Electrical Source Imaging for Mouse EEG: Application to an Fmr1 Knockout Model.

Electrical source imaging (ESI) reconstructs where in the brain a scalp EEG signal arises. It is routine in humans but unestablished in the mouse, whose brain is some 3,000 times smaller where it is not obvious that a sparse array can separate one region from another. We built an atlas-based ESI pipeline for 30-channel...

Alex D. Edmondson, Andrew D. Gaulden, Richard K. Lacher et al. · NeuroImage · 0 citations

Open access Jul 2026

FMR1 gene therapy restores translationally relevant phenotypes in a mouse model for fragile X syndrome.

It is shown that FMR1 gene therapy using delivery routes and vehicles approved for clinical use improves core phenotypes in a mouse model for FXS, and suggests that a dual route may be needed to achieve full brain coverage.

Richard K Lacher, Kari Henson, Lindsay N Wathen et al. · Gene Therapy · 0 citations