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Author

Riham A. El-Shiekh

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Oct 2026

Moghat, the roots of Glossostemon bruguieri (Desf.) as a nutraceutical against metabolic syndrome through PI3K/AKT/mTOR and TLR4-MYD88-p38 MAPK pathways.

OBJECTIVES This research was designed to assess the impact and underlying pathways of the root aqueous extract of Moghat root (MRE) on metabolic syndrome (MS). METHODS The extract's constituents were identified through HPLC analysis, followed by evaluation of its impact on lipid and glucose metabolism using in vitro...

Salma Mostafa Mohamed, Riham A. El-Shiekh, M. Rashad et al. · 0 citations
Review Open access Aug 2026

Aucubin as a multifunctional iridoid glycoside: Molecular pharmacology and therapeutic mechanisms supporting its potential as a drug discovery scaffold.

This review positions aucubin as a biologically informative iridoid glycoside with substantial scaffold-level relevance for future natural-product-inspired therapeutic development, rather than as a near-term clinical drug candidate.

M. Arafat, Mostafa K. Mohammad, Kareem A. Attallah et al. · 0 citations
Review Open access Aug 2026

Neurogenesis and neuroplasticity activities of natural products: therapeutic potential in Alzheimer’s disease

Overall, natural products represent promising candidates for managing neurogenesis and neuroplasticity in AD, although further clinical studies are required to validate their therapeutic efficacy.

A. Shaheen, Mou-Sa A. Mai, Merhan O. Hindam et al. · 2 citations
Aug 2026

Design, Synthesis, X‐Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene‐Pyrrolidine Derivatives as Multifunctional Anti‐Alzheimer Agents

In silico ADME profiling demonstrated promising pharmacokinetic behavior, characterized by robust gastrointestinal absorption and excellent predicted blood–brain barrier penetration, supporting the potential of these derivatives as promising multifunctional candidates for the development of anti‐Alzheimer agents.

Aisha A. Alsfouk, Riham A. El-Shiekh, Benson M Kariuki et al. · 0 citations
Open access Jul 2026

LC-QTOF-MS metabolic profiling and anti-MRSA activity of Asparagus officinalis L. spear methanolic extract in a skin infection mouse model

The findings obtained here demonstrate the potential of A. officinalis L. spears for pharmaceutical, agricultural, and food industry applications and demonstrates significant in vitro inhibition of the biofilm formation and enhanced biofilm detachment against MRSA.

Passent M. Abdel-Baki, Mariam Hassan, Noha A. Ahmed et al. · 0 citations

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