Rina Fujimoto

CRISPR-Mediated Epigenetic Reprogramming Attenuates Inflammatory Cell Injury Through Targeted Transcriptional Modulation: An Experimental in Vitro and in Vivo Study

Background Persistent NF-κB-driven inflammatory transcription promotes inflammasome activation, oxidative stress, mitochondrial dysfunction, and regulated cell death. Although CRISPR-based epigenome editing enables locus-specific transcriptional regulation without permanent modification of the underlying DNA sequence,...