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Author

Rinako Sugie

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Aug 2026

Rapamycin-sensitive mTORC1 signaling in the medial prefrontal cortex contributes to the antidepressant-like behavioral effects of shikimic acid in mice.

These findings suggest that SA exerts antidepressant-like effects via rapamycin-sensitive mTORC1-dependent mechanisms within the mPFC, and support SA as a candidate compound targeting mPFC mTORC1-related signaling for novel rapid-acting antidepressants.

Satoshi Deyama, Kana Ito-Shintai, Rinako Sugie et al. · 0 citations

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