Author

Riti Sharan

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Open access Jul 2026

Early immune dysregulation in Mtb/SIV co-infection resists cART treatment at the single-cell level

Summary Using single-cell transcriptomics of bronchoalveolar lavage cells from Mtb/SIV co-infected rhesus macaques on cART, we reveal profound immune dysregulation during early SIV co-infection of latent tuberculosis. SIV induces a sharp decline in CD4+ T cells, NK, and NKT cells, with incomplete recovery of Mtb-specif...

Riti Sharan, Yikun Zou, Zhao Lai et al. · iScience · 0 citations

Review Open access Jul 2026

From Primates to People: Mapping Host-Microbiome-Health Relationships in Aging.

The human microbiome profoundly influences host physiology, metabolism, and immune function. A balanced microbial ecosystem supports immune homeostasis and health, whereas dysbiosis contributes to diverse diseases, including metabolic, autoimmune, neurodegenerative, and infectious disorders. Aging, the greatest risk fa...

Angélica M. Olmo-Fontánez, K. Reveles, Riti Sharan et al. · Ageing Research Reviews · 0 citations