Open access
Aug 2026
Intranasal delivery of a COBRA-based protein vaccine adjuvanted with c-di-AMP enhances breadth of protective immune responses against seasonal influenza viruses
Pentavalent COBRA HA/NA intranasal vaccination adjuvanted with c-di-AMP induced strong humoral and cellular immune responses in murine models, highlighting the value of combining broadly protective COBRA vaccine candidates with advanced mucosal adjuvants to enhance efficacy against antigenically drifted influenza virus...
Camila C. S. Caetano, David A. Prots, Matthew H. Thomas et al.
· Frontiers in Immunology · 0 citations