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Author

Robert Howard

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Open access Aug 2026

Evaluating the impact of clinical trial design features on probability-of-success prediction

Estimating the probability of success (POS) of clinical trials remains a major challenge in drug development. Legacy forecasting approaches in the biopharmaceutical industry rely on historical averages stratified by development phase and therapy area, which obscures the contribution of trial design to clinical outcom...

Robert Howard, Beau Bush, Joseph Edelmann et al. · 0 citations
Review Open access Aug 2026

Blood-Based Biomarkers for Alzheimer Disease in Primary Care

Blood-based biomarkers (BBMs) for Alzheimer disease (AD) have accelerated the prospect of earlier and more accessible detection of AD pathology, potentially beyond specialist settings. However, their introduction in primary care raises important questions about clinical sequencing, interpretability, pathway consequence...

Jemma Hazan, S. Salemme, Kathy Y. Liu et al. · 0 citations

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