Author

Robert J. Bastidas

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Open access Oct 2026

Loss of PmpC in Chlamydia trachomatis leads to altered bacterial development and impaired recovery from IFNγ- and penicillin-induced stress

ABSTRACT Chlamydia trachomatis is an obligate intracellular pathogen that can reversibly halt replication and developmental transitions in response to immunological or pharmacological stress, a phenomenon linked to chlamydial persistence. Although polymorphic membrane proteins (Pmps) are known adhesins, their broader r...

Ailen N. Anna, M. Panzetta, Gloria N. Bettucci Ferrero et al. · Microbiology spectrum · 0 citations

Open access Aug 2026

RNF213-dependent lytic destruction of Chlamydia-containing vacuoles activates host cell death pathways

The cytokine gamma-interferon (IFNγ) promotes antimicrobial cell-autonomous immunity by inducing hundreds of interferon-stimulated genes (ISGs). Among these ISGs is the ubiquitin E3 ligase RNF213 which protects host cells from a wide range of intracellular pathogens including the obligate intracellular bacterium Chlamy...

Mary S. Dickinson, Stephen C. Walsh, Robert J. Bastidas et al. · Proceedings of the National... · 0 citations