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Robert Köchl

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Review Open access Oct 2026

Beyond ion homeostasis: WNK1 and the role of water influx in T cell biology

The serine-threonine kinase WNK1 is a regulator of ion homeostasis and cell volume control studied most extensively in the kidney. WNK1 phosphorylates and activates the OXSR1 and STK39 kinases, which in turn phosphorylate members of the SLC12A-family of ion co-transporters resulting in influx of Na + , K + and Cl...

Robert Köchl, Victor L. J. Tybulewicz · 0 citations

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