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Author

Robert M. Bragg

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Open access Jul 2026

Hepatic huntingtin loss drives an acute phase response and liver injury in multiple mouse models

Multiple therapeutic strategies are being developed to slow Huntington’s disease (HD) progression through targeted reduction of huntingtin (HTT) protein or mRNA. Despite HTT’s discovery over 30 years ago, its cellular functions remain incompletely understood, and the long-term consequences of HTT-lowering therapies rem...

Colby L. Samstag, Robert M. Bragg, Kelsie Neumann et al. · 0 citations

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