Robert S. Chapkin

Single-cell gene regulatory networks characterize colonic stem and immune cell homeostasis in Nr4a1 knockout mice

Summary Recent findings suggest that the orphan nuclear receptor 4A (NR4A) can regulate cellular energetics and epithelial defenses, contributing to a resilient, disease-resistant phenotype. To further examine the effects of NR4A on intestinal epithelial, stromal, and immune cell homeostasis, we performed single-cell t...